DISSOCIATION

DP1*:E2F1_Lys_ace:PCAF@nucleus - ATR@nucleus - ATM_Ser 1981_pho@nucleus -> DP1*:E2F1_Lys_ace_Ser31_pho@nucleus+PCAF@nucleus
center map on species (center map)
Comments:

PMID:15838517 PMID:15140942 14-3-3 tau mediates E2F1 stabilization. 14-3-3 tau interacts with ATM-phosphorylated E2F1 during DNA damage and inhibits E2F1 ubiquitination. 14-3-3 tau is also required for expression and induction of E2F1 apoptotic targets, such as p73, Apaf-1, and caspases, during DNA damage. PMID:15494392

In modules:
  1. Module: Apoptosis_entry
  2. Module: E2F1-3