STATE_TRANSITION
p53*@nucleus - CHEK2_Thr68_pho@nucleus - ATR@nucleus - ATM_Ser 1981_pho:NBS1__pho@nucleus -> p53*_Ser15_pho@nucleus
(center map)
Comments:
PMID:15024084 ATM phosphorylates p53 in case of DNA double-strand breaks. ATR phosphorylates p53 in case of other types of DNA damages. PMID:15140942 E2F1 stimulates ATM to phosphorylate p53 (and Chk2) PMID:15140942 (ref REACTOME) PMID:9843217 PMID:9733515 PMID:9733514
In modules:
- Module: Apoptosis_entry