DP2*:E2F4:p107*@nucleus - CDK6__pho:cyclin D1*:p27Kip1*@nucleus - CDK4__pho:cyclin D1*:p27Kip1*@nucleus - CDK4:cyclin D1*:p21Cip*@nucleus - CDK6:cyclin D1*:p21Cip*@nucleus - CDK6__pho:cyclin D1*:p27Kip1*@nucleus -> DP2*:E2F4:p107*__pho@nucleus DP2*:E2F4:p107*__pho@nucleus -> p107*__pho@nucleus+DP2*@nucleus+E2F4@nucleus DP2*:E2F4:p107*__pho@nucleus -> p107*__pho@nucleus+DP2*@nucleus+E2F4@nucleus DP2*:E2F4:p107*__pho@nucleus -> p107*__pho@nucleus+DP2*@nucleus+E2F4@nucleus E2F4@nucleus -t-> E2F4@cell DP2*:E2F4@nucleus+p107*@nucleus -> DP2*:E2F4:p107*@nucleus DP2*:E2F4@nucleus+p107*@nucleus -> DP2*:E2F4:p107*@nucleus DP2*:E2F4@nucleus+p107*@nucleus -> DP2*:E2F4:p107*@nucleus DP1*:E2F1@nucleus+pRB*@nucleus -> DP1*:E2F1:pRB*@nucleus DP1*:E2F1@nucleus+pRB*@nucleus -> DP1*:E2F1:pRB*@nucleus DP1*:E2F1@nucleus+pRB*@nucleus -> DP1*:E2F1:pRB*@nucleus DP2*@nucleus -t-> DP2*@cell E2F1__pho@nucleus -> E2F1@nucleus E2F1__pho__ace@nucleus - HDAC1@nucleus -> E2F1__pho@nucleus E2F cofactors@cell BMI1*:DP2*:E2F6:MEL-18*:PHC1:RING1:RYBP@nucleus DP1*:E2F1:SWI/SNF:pRB*__pho__pho@nucleus EED@nucleus BAT8:DP1*:E2F6:EHMT1:HP1gamma*:MAX:MGA@nucleus SWI/SNF__pho@nucleus DP1*:E2F1:HDAC1:SWI/SNF:pRB*__pho@nucleus DP1*:E2F6:MAX:MGA@nucleus CDC2__pho:cyclin B1*@nucleus BAT8:DP1*:E2F6:EHMT1:MAX:MGA@nucleus CDK2__pho__pho:cyclin E1*@nucleus ATR@nucleus gCDKN2C@genes CHEK2__pho@nucleus CDC37:HSP90_hm2@cell gCDC2@genes gp21Cip*@genes DP2*:E2F4:p107*__pho@nucleus gCCND3@genes gCyclin E*@genes DP2*:E2F4:p130*@cell -t-> DP2*:E2F4:p130*@nucleus p107*__pho@nucleus gCBX5@genes gcyclin A2*@genes gBBC3@genes MAX:MGA@nucleus gBCL2L11@genes EHMT1@nucleus BAT8@nucleus gAXIN2@genes null@nucleus DP2*:E2F4:HDAC1:SIN3B:SUV39H1:p130*@nucleus null@nucleus PKMYT1@cell DP1*:E2F1__ace@nucleus+PCAF@nucleus -> DP1*:E2F1__ace:PCAF@nucleus DP1*:E2F1__ace@nucleus+PCAF@nucleus -> DP1*:E2F1__ace:PCAF@nucleus DP1*:E2F1__ace@nucleus+PCAF@nucleus -> DP1*:E2F1__ace:PCAF@nucleus E2F1@nucleus+DP1*@nucleus -> DP1*:E2F1@nucleus E2F1@nucleus+DP1*@nucleus -> DP1*:E2F1@nucleus E2F1@nucleus+DP1*@nucleus -> DP1*:E2F1@nucleus CDC37:CDK4:HSP90_hm2@cell gMCAM@genes gMCL1@genes gGMNN@genes gISYNA1@genes gJMY@genes gLGALS1@genes gcarboxylesterase*@genes DP2*:E2F4:p107*@nucleus gCox IV*@genes gEED@genes gEZH2@genes MGA@nucleus DP1*@cell - E2F1@nucleus -t-> DP1*@nucleus MAX@nucleus HP1gamma*@nucleus CDK4@cell CDC37:CDK4__don@cell DP1*:E2F1@nucleus - EP300@nucleus - CREBBP@nucleus - PCAF@nucleus -> DP1*:E2F1__ace@nucleus gRBBP4@genes E2F8@nucleus -> E2F8_hm2@nucleus PP1@nucleus gMXD3@genes gNPAT@genes gMCM10@genes gMYB@genes gPMAIP1@genes gPNRC2@genes gp14ARF*@genes gPCNA@genes DP1*:E2F6:EED:EPC1:EZH2@nucleus gMCM3@genes CDC37@cell HSP90_hm2@cell p21Cip*@nucleus HSP90@cell gCDC20@genes gKPNA2@genes gMCM6@genes gE2F2@genes gE2F7@genes gE2F6@genes gE2F3@genes gE2F1@genes E2F1__pho@nucleus DP2*@nucleus CDK6:cyclin D1*__pho@nucleus gBUB1@genes CDK6:cyclin D1*__pho@cell gRBBP8@genes DP1*__pho:E2F1__pho__ace:PCAF@nucleus -> PCAF@nucleus+E2F1__pho__ace@nucleus+DP1*__pho@nucleus DP1*__pho:E2F1__pho__ace:PCAF@nucleus -> PCAF@nucleus+E2F1__pho__ace@nucleus+DP1*__pho@nucleus DP1*__pho:E2F1__pho__ace:PCAF@nucleus -> PCAF@nucleus+E2F1__pho__ace@nucleus+DP1*__pho@nucleus DP1*@cell+E2F6@cell -> DP1*:E2F6@cell DP1*@cell+E2F6@cell -> DP1*:E2F6@cell DP1*@cell+E2F6@cell -> DP1*:E2F6@cell CDK4:cyclin D1*__pho@cell DP1*:E2F1__ace:PCAF@nucleus - CDK2__pho:cyclin A2*@nucleus -> DP1*__pho:E2F1__pho__ace:PCAF@nucleus CDK4:cyclin D1*__pho@nucleus DP1*:E2F6:EED:EPC1:EZH2:SIN3B@nucleus CDK6:cyclin D1*@nucleus CDK4:cyclin D1*@nucleus MDM2@cell -t-> MDM2@nucleus MDM2:p53*@nucleus -t-> MDM2:p53*@cell DP1*:E2F1__ace:PCAF@nucleus - CHEK2__pho@nucleus - CHEK2@nucleus -> PCAF@nucleus+DP1*:E2F1__ace__pho@nucleus DP1*:E2F1__ace:PCAF@nucleus - CHEK2__pho@nucleus - CHEK2@nucleus -> PCAF@nucleus+DP1*:E2F1__ace__pho@nucleus DP1*:E2F1__ace:PCAF@nucleus - CHEK2__pho@nucleus - CHEK2@nucleus -> PCAF@nucleus+DP1*:E2F1__ace__pho@nucleus DP1*:E2F1__ace:PCAF@nucleus - ATR@nucleus - ATM__pho@nucleus -> DP1*:E2F1__ace__pho@nucleus+PCAF@nucleus DP1*:E2F1__ace:PCAF@nucleus - ATR@nucleus - ATM__pho@nucleus -> DP1*:E2F1__ace__pho@nucleus+PCAF@nucleus DP1*:E2F1__ace:PCAF@nucleus - ATR@nucleus - ATM__pho@nucleus -> DP1*:E2F1__ace__pho@nucleus+PCAF@nucleus CDK4__pho:cyclin D1*:p27Kip1*@nucleus CDK4:cyclin D1*:p27Kip1*@nucleus E2F6@nucleus -t-> E2F6@cell CDK6__pho:cyclin D1*:p27Kip1*@nucleus p21Cip*@nucleus - AKT1@nucleus -> p21Cip*__pho@nucleus p21Cip*__pho@nucleus -t-> p21Cip*__pho@cell CDK2:cyclin E1*:p27Kip1*@nucleus CDK6:cyclin D1*:p27Kip1*@nucleus CDK2:cyclin A2*:p27Kip1*@nucleus p27Kip1*@nucleus p27Kip1*__pho@nucleus DP2*:E2F4:HDAC1:SIN3B:SUV39H1:p130*__pho@nucleus -> p130*__pho@nucleus+HDAC1@nucleus+SIN3B@nucleus+SUV39H1@nucleus+DP2*:E2F4@nucleus DP2*:E2F4:HDAC1:SIN3B:SUV39H1:p130*__pho@nucleus -> p130*__pho@nucleus+HDAC1@nucleus+SIN3B@nucleus+SUV39H1@nucleus+DP2*:E2F4@nucleus DP2*:E2F4:HDAC1:SIN3B:SUV39H1:p130*__pho@nucleus -> p130*__pho@nucleus+HDAC1@nucleus+SIN3B@nucleus+SUV39H1@nucleus+DP2*:E2F4@nucleus DP1*:E2F1:pRB*__pho__pho__pho@nucleus -> pRB*__pho__pho__pho@nucleus+DP1*:E2F1@nucleus DP1*:E2F1:pRB*__pho__pho__pho@nucleus -> pRB*__pho__pho__pho@nucleus+DP1*:E2F1@nucleus DP1*:E2F1:pRB*__pho__pho__pho@nucleus -> pRB*__pho__pho__pho@nucleus+DP1*:E2F1@nucleus BMI1*:MEL-18*:PHC1:RING1:RYBP@nucleus+DP2*:E2F6@nucleus -> BMI1*:DP2*:E2F6:MEL-18*:PHC1:RING1:RYBP@nucleus BMI1*:MEL-18*:PHC1:RING1:RYBP@nucleus+DP2*:E2F6@nucleus -> BMI1*:DP2*:E2F6:MEL-18*:PHC1:RING1:RYBP@nucleus BMI1*:MEL-18*:PHC1:RING1:RYBP@nucleus+DP2*:E2F6@nucleus -> BMI1*:DP2*:E2F6:MEL-18*:PHC1:RING1:RYBP@nucleus DP1*:E2F1:HDAC1:SWI/SNF:pRB*__pho@nucleus - CDK6__pho:cyclin D1*:p27Kip1*@nucleus - CDK4__pho:cyclin D1*:p27Kip1*@nucleus - CDK4:cyclin D1*:p21Cip*@nucleus - CDK6:cyclin D1*:p21Cip*@nucleus -> HDAC1@nucleus+DP1*:E2F1:SWI/SNF:pRB*__pho__pho@nucleus DP1*:E2F1:HDAC1:SWI/SNF:pRB*__pho@nucleus - CDK6__pho:cyclin D1*:p27Kip1*@nucleus - CDK4__pho:cyclin D1*:p27Kip1*@nucleus - CDK4:cyclin D1*:p21Cip*@nucleus - CDK6:cyclin D1*:p21Cip*@nucleus -> HDAC1@nucleus+DP1*:E2F1:SWI/SNF:pRB*__pho__pho@nucleus DP1*:E2F1:HDAC1:SWI/SNF:pRB*__pho@nucleus - CDK6__pho:cyclin D1*:p27Kip1*@nucleus - CDK4__pho:cyclin D1*:p27Kip1*@nucleus - CDK4:cyclin D1*:p21Cip*@nucleus - CDK6:cyclin D1*:p21Cip*@nucleus -> HDAC1@nucleus+DP1*:E2F1:SWI/SNF:pRB*__pho__pho@nucleus DP1*:E2F1__ace@nucleus - HDAC1@nucleus -> DP1*:E2F1@nucleus DP2*:E2F4:HDAC1:SIN3B:SUV39H1:p130*@nucleus - CDK2__pho:cyclin E1*@nucleus - CDK6__pho:cyclin D1*:p27Kip1*@nucleus - CDK4__pho:cyclin D1*:p27Kip1*@nucleus - CDK6:cyclin D1*:p21Cip*@nucleus - CDK4:cyclin D1*:p21Cip*@nucleus -> DP2*:E2F4:HDAC1:SIN3B:SUV39H1:p130*__pho@nucleus DP1*:E2F6:EED:EPC1:EZH2@nucleus+SIN3B@nucleus -> DP1*:E2F6:EED:EPC1:EZH2:SIN3B@nucleus DP1*:E2F6:EED:EPC1:EZH2@nucleus+SIN3B@nucleus -> DP1*:E2F6:EED:EPC1:EZH2:SIN3B@nucleus DP1*:E2F6:EED:EPC1:EZH2@nucleus+SIN3B@nucleus -> DP1*:E2F6:EED:EPC1:EZH2:SIN3B@nucleus HDAC1:SIN3B@nucleus+DP2*:E2F4:p130*@nucleus+SUV39H1@nucleus -> DP2*:E2F4:HDAC1:SIN3B:SUV39H1:p130*@nucleus HDAC1:SIN3B@nucleus+DP2*:E2F4:p130*@nucleus+SUV39H1@nucleus -> DP2*:E2F4:HDAC1:SIN3B:SUV39H1:p130*@nucleus HDAC1:SIN3B@nucleus+DP2*:E2F4:p130*@nucleus+SUV39H1@nucleus -> DP2*:E2F4:HDAC1:SIN3B:SUV39H1:p130*@nucleus MAX:MGA@nucleus+DP1*:E2F6@nucleus -> DP1*:E2F6:MAX:MGA@nucleus MAX:MGA@nucleus+DP1*:E2F6@nucleus -> DP1*:E2F6:MAX:MGA@nucleus MAX:MGA@nucleus+DP1*:E2F6@nucleus -> DP1*:E2F6:MAX:MGA@nucleus DP1*:E2F6:EPC1@nucleus+EZH2@nucleus+EED@nucleus -> DP1*:E2F6:EED:EPC1:EZH2@nucleus DP1*:E2F6:EPC1@nucleus+EZH2@nucleus+EED@nucleus -> DP1*:E2F6:EED:EPC1:EZH2@nucleus DP1*:E2F6:EPC1@nucleus+EZH2@nucleus+EED@nucleus -> DP1*:E2F6:EED:EPC1:EZH2@nucleus DP1*:E2F6:MAX:MGA@nucleus+BAT8@nucleus+EHMT1@nucleus -> BAT8:DP1*:E2F6:EHMT1:MAX:MGA@nucleus DP1*:E2F6:MAX:MGA@nucleus+BAT8@nucleus+EHMT1@nucleus -> BAT8:DP1*:E2F6:EHMT1:MAX:MGA@nucleus DP1*:E2F6:MAX:MGA@nucleus+BAT8@nucleus+EHMT1@nucleus -> BAT8:DP1*:E2F6:EHMT1:MAX:MGA@nucleus BAT8:DP1*:E2F6:EHMT1:MAX:MGA@nucleus+HP1gamma*@nucleus -> BAT8:DP1*:E2F6:EHMT1:HP1gamma*:MAX:MGA@nucleus BAT8:DP1*:E2F6:EHMT1:MAX:MGA@nucleus+HP1gamma*@nucleus -> BAT8:DP1*:E2F6:EHMT1:HP1gamma*:MAX:MGA@nucleus BAT8:DP1*:E2F6:EHMT1:MAX:MGA@nucleus+HP1gamma*@nucleus -> BAT8:DP1*:E2F6:EHMT1:HP1gamma*:MAX:MGA@nucleus MDM2:p53*@cell -> p53*@cell+MDM2@cell p53*@cell -> DP1*@cell+p14ARF*@nucleus -> DP1*:p14ARF*@nucleus DP1*@cell+p14ARF*@nucleus -> DP1*:p14ARF*@nucleus DP1*@cell+p14ARF*@nucleus -> DP1*:p14ARF*@nucleus p27Kip1*__pho@nucleus -t-> p27Kip1*__pho@cell E2F3_alone@cell --> gTP53BP2 E2F1:p14ARF*@nucleus -t-> E2F1:p14ARF*@nucleole E2F4@nucleus --| gTOPBP1 E2F1_alone@cell --> gTOPBP1 E2F1@nucleus+p14ARF*@nucleus -> E2F1:p14ARF*@nucleus E2F1@nucleus+p14ARF*@nucleus -> E2F1:p14ARF*@nucleus E2F1@nucleus+p14ARF*@nucleus -> E2F1:p14ARF*@nucleus E2F1_alone@cell --> gTOP2A E2F4@nucleus --> gTOP2A E2F1_alone@cell --> gUBB E2F1@nucleus - p14ARF*@nucleus -> E2F1_alone@cell --> gUHRF1 E2F6@nucleus --> gTUBA3 E2F4@nucleus --> gTRIM55 E2F4@nucleus --| gTYMS DP1*:p14ARF*@nucleus -t-> DP1*:p14ARF*@nucleole p27Kip1*@nucleus - AKT1@nucleus -> p27Kip1*__pho@nucleus E2F3_alone@cell --> gTYMS PCNA@nucleus+p21Cip*@nucleus -> PCNA:p21Cip*@nucleus PCNA@nucleus+p21Cip*@nucleus -> PCNA:p21Cip*@nucleus PCNA@nucleus+p21Cip*@nucleus -> PCNA:p21Cip*@nucleus E2F1_alone@cell --> gWWOX CDH1*__pho@nucleus - CDC14A@nucleus -> CDH1*@nucleus cyclin B1*@nucleus - APC:CDC20__pho@nucleus -> E2F6@nucleus --| gTYMS E2F4@nucleus --> gZNF451 MDM2:p14ARF*@nucleus -t-> MDM2:p14ARF*@nucleole E2F6@nucleus --> gZNF451 CDC25C__pho@nucleus - CHEK1__pho__pho@nucleus - CHEK2__pho@nucleus -> CDC25C__pho__pho@nucleus E2F4@nucleus --> gZNF83 CDC25C__pho__pho@nucleus -t-> CDC25C__pho__pho@cell E2F6@nucleus --> gZNF83 E2F3_alone@cell --> gUXT E2F1_alone@cell --> gZNF451 E2F6@nucleus --> gWDR36 CDH1*@nucleus - CDK2__pho:cyclin A2*@nucleus - CDC2__pho:cyclin B1*@nucleus -> CDH1*__pho@nucleus cyclin A2*@nucleus - APC:CDC20__pho@nucleus - APC:CDH1*@nucleus -> E2F2_alone@cell --> gMCM8 CDH1*@nucleus+APC@nucleus -> APC:CDH1*@nucleus CDH1*@nucleus+APC@nucleus -> APC:CDH1*@nucleus CDH1*@nucleus+APC@nucleus -> APC:CDH1*@nucleus E2F3_alone@cell --> gMCM8 cyclin E1*__pho@nucleus -> E2F4@nucleus --> gMCM8 CDC20@nucleus - CDC2__pho:cyclin B1*@nucleus -> CDC20__pho@nucleus E2F1_alone@cell --> gSIVA APC@nucleus+CDC20__pho@nucleus -> APC:CDC20__pho@nucleus APC@nucleus+CDC20__pho@nucleus -> APC:CDC20__pho@nucleus APC@nucleus+CDC20__pho@nucleus -> APC:CDC20__pho@nucleus CDK2__pho@nucleus - CDKN3@nucleus -> CDK2@nucleus CDK2__pho:cyclin E1*__pho@nucleus -> cyclin E1*__pho@nucleus+CDK2__pho@nucleus CDK2__pho:cyclin E1*__pho@nucleus -> cyclin E1*__pho@nucleus+CDK2__pho@nucleus CDK2__pho:cyclin E1*__pho@nucleus -> cyclin E1*__pho@nucleus+CDK2__pho@nucleus E2F4@nucleus --> gSPAG7 E2F1_alone@cell --| gSNX19 E2F4@nucleus --> gSLC3A2 E2F4@nucleus --> gSLC25A14 E2F4@nucleus --> gSOAT2 CDK7:MNAT1:cyclin H*@nucleus -> CDK7__pho:MNAT1:cyclin H*@nucleus CDK4@cell+p16INK4a*@cell - SERTAD1@cell -> CDK4:p16INK4a*@cell CDK4@cell+p16INK4a*@cell - SERTAD1@cell -> CDK4:p16INK4a*@cell CDK4@cell+p16INK4a*@cell - SERTAD1@cell -> CDK4:p16INK4a*@cell CDK2__pho:cyclin E1*@nucleus - GSK3B@nucleus -> CDK2__pho:cyclin E1*__pho@nucleus E2F1_alone@cell --> gSUZ12 cyclin D1*__pho@cell -> E2F1_alone@cell --> gSTMN1 CDK6:cyclin D1*__pho@cell -> cyclin D1*__pho@cell+CDK6@cell CDK6:cyclin D1*__pho@cell -> cyclin D1*__pho@cell+CDK6@cell CDK6:cyclin D1*__pho@cell -> cyclin D1*__pho@cell+CDK6@cell E2F4@nucleus --> gSRPR CDK4:cyclin D1*__pho@cell -> cyclin D1*__pho@cell+CDK4@cell CDK4:cyclin D1*__pho@cell -> cyclin D1*__pho@cell+CDK4@cell CDK4:cyclin D1*__pho@cell -> cyclin D1*__pho@cell+CDK4@cell E2F1_alone@cell --> gSSR4 CDC2__pho__pho:cyclin B1*@nucleus - CDC25C__pho@nucleus -> CDC2__pho:cyclin B1*@nucleus E2F6@nucleus --> gSPAG7 E2F1_alone@cell --> gTP53BP2 E2F1_alone@cell --> gTP53INP1 E2F2_alone@cell --> gTP53BP2 E2F4@nucleus --| gSTMN1 E2F1_alone@cell --> gTHEM2 CDC2:cyclin B1*@cell - PKMYT1@cell -> CDC2__pho:cyclin B1*@cell CDC2__pho__pho:cyclin B1*@cell - CDC25C@cell -> CDC2__pho:cyclin B1*@cell CDC2__pho:cyclin B1*@cell - PKMYT1@cell -> CDC2__pho__pho:cyclin B1*@cell CDC2__pho:cyclin B1*@cell - CDC25C@cell -> CDC2:cyclin B1*@cell CDC2__pho:cyclin B1*@cell -t-> CDC2__pho:cyclin B1*@nucleus CDC2__pho:cyclin B1*@nucleus -t-> CDC2__pho:cyclin B1*@cell CDC2:cyclin B1*@cell - PKMYT1@cell -> CDC2__pho:cyclin B1*@cell CDC2__pho__pho:cyclin B1*@cell - CDC25C@cell -> CDC2__pho:cyclin B1*@cell CDC2__pho:cyclin B1*@cell - PKMYT1@cell -> CDC2__pho__pho:cyclin B1*@cell DP2*:E2F4@cell+p130*@cell -> DP2*:E2F4:p130*@cell DP2*:E2F4@cell+p130*@cell -> DP2*:E2F4:p130*@cell DP2*:E2F4@cell+p130*@cell -> DP2*:E2F4:p130*@cell E2F4@nucleus --| gTK1 E2F4@nucleus --> gE2F8 CDC2__pho:cyclin B1*@nucleus -t-> CDC2__pho:cyclin B1*@cell CDC2__pho:cyclin B1*@cell -t-> CDC2__pho:cyclin B1*@nucleus CDC2__pho:cyclin B1*@cell - CDC25C@cell -> CDC2:cyclin B1*@cell E2F1_alone@cell --> gE2F8 E2F3_alone@cell --> gASK E2F1_alone@cell --> gPOLA E2F6@nucleus --| gTK1 CDC2:cyclin B1*@nucleus - WEE1@nucleus -> CDC2__pho:cyclin B1*@nucleus E2F1_alone@cell --> gSIP* CDC2__pho:cyclin B1*@nucleus - CDC25C__pho@nucleus -> CDC2:cyclin B1*@nucleus E2F4@nucleus --| gTP73 CDC2:cyclin B1*@cell -t-> CDC2:cyclin B1*@nucleus E2F3_alone@cell --| gTP73 CDC25C@cell -t-> CDC25C@nucleus CDC2__pho__pho:cyclin B1*@cell -t-> CDC2__pho__pho:cyclin B1*@nucleus CDC2__pho__pho:cyclin B1*@nucleus - CDC25C__pho@nucleus -> CDC2__pho:cyclin B1*@nucleus E2F3_alone@cell --> gTK1 CDC2:cyclin B1*@nucleus - CDK7__pho:MNAT1:cyclin H*@nucleus -> CDC2__pho:cyclin B1*@nucleus E2F6@nucleus --| gPOLA CDC2__pho:cyclin B1*@nucleus - CDC25C__pho@nucleus -> CDC2:cyclin B1*@nucleus p21Cip*@nucleus - CDK2:cyclin A2*@nucleus -> p21Cip*__pho@nucleus CDC2__pho:cyclin B1*@nucleus - WEE1@nucleus -> CDC2__pho__pho:cyclin B1*@nucleus p130*__pho@nucleus+CDK2:cyclin A2*@nucleus -> CDK2:cyclin A2*:p130*__pho@nucleus p130*__pho@nucleus+CDK2:cyclin A2*@nucleus -> CDK2:cyclin A2*:p130*__pho@nucleus p130*__pho@nucleus+CDK2:cyclin A2*@nucleus -> CDK2:cyclin A2*:p130*__pho@nucleus p107*@nucleus+CDK2:cyclin A2*@nucleus -> CDK2:cyclin A2*:p107*@nucleus p107*@nucleus+CDK2:cyclin A2*@nucleus -> CDK2:cyclin A2*:p107*@nucleus p107*@nucleus+CDK2:cyclin A2*@nucleus -> CDK2:cyclin A2*:p107*@nucleus p130*__pho@nucleus+CDK2__pho:cyclin E1*@nucleus -> CDK2__pho:cyclin E1*:p130*__pho@nucleus p130*__pho@nucleus+CDK2__pho:cyclin E1*@nucleus -> CDK2__pho:cyclin E1*:p130*__pho@nucleus p130*__pho@nucleus+CDK2__pho:cyclin E1*@nucleus -> CDK2__pho:cyclin E1*:p130*__pho@nucleus CDK2__pho:cyclin E1*@nucleus+p107*@nucleus -> CDK2__pho:cyclin E1*:p107*@nucleus CDK2__pho:cyclin E1*@nucleus+p107*@nucleus -> CDK2__pho:cyclin E1*:p107*@nucleus CDK2__pho:cyclin E1*@nucleus+p107*@nucleus -> CDK2__pho:cyclin E1*:p107*@nucleus E2F cofactors@cell -?> E2F3_alone@cell CDC2__pho__pho:cyclin B1*@nucleus -t-> CDC2__pho__pho:cyclin B1*@cell CDC2@cell+cyclin B1*@cell -> CDC2:cyclin B1*@cell CDC2@cell+cyclin B1*@cell -> CDC2:cyclin B1*@cell CDC2@cell+cyclin B1*@cell -> CDC2:cyclin B1*@cell E2F cofactors@cell -?> E2F1_alone@cell DP2*@cell+E2F4@cell -> DP2*:E2F4@cell DP2*@cell+E2F4@cell -> DP2*:E2F4@cell DP2*@cell+E2F4@cell -> DP2*:E2F4@cell PKMYT1@cell -> PKMYT1__pho@cell p53*@nucleus p53*__pho@nucleus NBS1__pho@nucleus p53*__pho__pho@nucleus E2F4@nucleus --> gCDCA4 E2F3_alone@cell --> gCDCA4 E2F2_alone@cell --> gCDCA4 p130*@cell E2F1_alone@cell --> gCDCA4 DP2*@cell E2F1_alone@cell --> gBMI1 E2F4@cell E2F6@nucleus --> gBRD7 DP1*:E2F1:pRB*__pho__pho__pho@nucleus p107*@nucleus E2F6@nucleus --| gUXT DP1*@cell E2F4@nucleus --> gUXT DP2*:E2F4:p130*@cell E2F2_alone@cell --> gUXT p130*__pho@nucleus E2F1_alone@cell --> gUXT E2F4@nucleus --> gCDCA7 BMI1*:MEL-18*:PHC1:RING1:RYBP@nucleus DP1*__pho@nucleus DP2*:E2F4@nucleus E2F4@nucleus --| gUDG1A DP1*__pho:E2F1__pho__ace:PCAF@nucleus E2F3_alone@cell --> gTERT E2F2_alone@cell --> gTERT E2F5@nucleus --> gTERT E2F4@nucleus --> gTERT E2F1_alone@cell --> gCDCA7 E2F3_alone@cell --> gCDCA7 E2F1_alone@cell --> gPURALPHA E2F2_alone@cell --> gCDCA7 CDK2__pho:cyclin E1*:p21Cip*@nucleus CDK2__pho:cyclin A2*:p21Cip*@nucleus CDK6:cyclin D1*:p21Cip*@nucleus CDK4:cyclin D1*:p21Cip*@nucleus MDM2:p53*@cell CDK2:cyclin A2*:p107*@nucleus CDC2__pho:cyclin B1*:p21Cip*@nucleus CDK2__pho:cyclin E1*:p130*__pho@nucleus CDK2:cyclin A2*:p130*__pho@nucleus E2F5 cofactors@cell -?> E2F5@nucleus E2F6 cofactors@cell -?> E2F6@nucleus E2F4 cofactors@cell -?> E2F4@nucleus E2F cofactors@cell -?> E2F2_alone@cell E2F7 cofactors@cell -?> E2F7@nucleus E2F8 cofactors@cell -?> E2F8@nucleus CDK2__pho:cyclin A2*@nucleus CDC25C@nucleus SUV39H1@nucleus CREBBP@nucleus EP300@nucleus E2F2_alone@cell --> gcyclin A2* MDM2:p14ARF*@nucleus E2F2_alone@cell --> gBCL2 p16INK4a*@cell E2F2_alone@cell --> gBIRC5 gRBM25@genes E2F6@nucleus --| gPCNA gPFKFB*@genes E2F6@nucleus -?> gRAD51AP1 gBCL2@genes E2F5 cofactors@cell E2F6@nucleus --| gp68* E2F6@nucleus --| gRRM1 E2F6@nucleus --| gRRM2 gCASP7@genes E2F6@nucleus --| gRBBP4 gSIP*@genes E2F6@nucleus --| gRBBP8 E2F8 cofactors@cell E2F7 cofactors@cell gCCNB2@genes gECE1B@genes CDK4:p16INK4a*@cell CDK6:p16INK4a*@cell E2F6@nucleus -?> gEXOSC8 MDM2:p53*@nucleus E2F6@nucleus --| gH19 E2F6@nucleus -?> gMCM3 E2F6@nucleus -?> gMYC E2F6@nucleus -| gCDC6 E2F6@nucleus -?> gCDC25A E2F6@nucleus -?> gCHEK2 E2F6@nucleus --| gCYC E2F6@nucleus -?> gDDX11 E2F6@nucleus -?> gE2F1 p14ARF*@nucleus ATM__pho:NBS1__pho@nucleus CDC2__pho__pho:cyclin B1*@cell NBS1@nucleus MDM2__pho@nucleus CDC2:cyclin B1*@cell E2F2_alone@cell -?> gMYC gRQCD1@genes E2F2_alone@cell --> gMELK gRFC5@genes E2F2_alone@cell -?> gMYBL2 gKNTC2@genes E2F2_alone@cell --> gGMNN gJPH2@genes E2F2_alone@cell --> gMCM7 gHOXA3@genes E2F2_alone@cell --> gEZH2 gFGFR1@genes E2F2_alone@cell -?> gGAB2 gFBXO5@genes E2F2_alone@cell -?> gECE1C gDRF1@genes E2F2_alone@cell --> gEED gCSTF1@genes TOPBP1@nucleus E2F2_alone@cell -?> gECE1B gCSTF3@genes PKMYT1__pho@cell CDC2__pho__pho:cyclin B1*@nucleus CDC25C@cell CDC25C__pho@nucleus CDC2:cyclin B1*@nucleus SWI/SNF@nucleus E2F2_alone@cell -?> gDHFR E2F2_alone@cell --> gE2F1 SERTAD1@cell HP1gamma*:SUV39H1@nucleus p15INK4b*@cell gRPL8@genes CHEK2@nucleus E2F2_alone@cell --> gCDC6 gRPA2@genes E2F2_alone@cell --> gCDKN2C E2F2_alone@cell --> gCDT1 gCCNE1@genes ATM__pho@nucleus E2F2_alone@cell --> gCNAP1 gH19@genes E2F2_alone@cell --> gcyclin B1* gDHFR@genes E2F2_alone@cell --> gCCND3 gPPP1R13B@genes E2F2_alone@cell --> gCyclin E* gPPARG@genes E2F2_alone@cell --> gCDC2 gASK@genes gCASP3@genes gCYC@genes CDK6:p15INK4b*@cell CDC2__pho:cyclin B1*@nucleus CDK4:p15INK4b*@cell DP2*:E2F4@cell E2F3_alone@cell E2F3_alone@cell --> gCDC6 E2F1_alone@cell E2F3_alone@cell --> gCDC2 E2F3_alone@cell -?> gCCNE1 E2F Family@cell E2F3_alone@cell --> gCyclin E* gATM@genes gMCM7@genes DP1*__pho@nucleus -> DP1*@nucleus E2F3_alone@cell --> gp21Cip* E2F2_alone@cell E2F3_alone@cell --| gCDC25A gRBL1@genes E2F3_alone@cell -?> gCDC20 gRRM2@genes gPBK@genes cyclin D1*__pho@cell null@cell CDC2__pho:cyclin B1*@nucleus CDC2__pho:cyclin B1*@cell CDK7:MNAT1:cyclin H*@nucleus CDC2__pho:cyclin B1*@cell E2F3_alone@cell -?> gCCNB2 E2F3_alone@cell --> gCCND3 E2F3_alone@cell --> gcyclin B1* gRPL32@genes E2F2_alone@cell --> gPCNA gp68*@genes E2F2_alone@cell --> gp14ARF* gRRM1@genes E2F1_alone@cell - E2F1_alone@cell --> gRBL1 gSERPINE1@genes E2F2_alone@cell --> gPPP1R13B gECE1C@genes E2F3_alone@cell --> gBIRC5 gACR@genes E2F3_alone@cell --> gATM gBARD1@genes HDAC1@nucleus+DP1*:E2F1:pRB*@nucleus+SWI/SNF@nucleus -> DP1*:E2F1:HDAC1:SWI/SNF:pRB*@nucleus HDAC1@nucleus+DP1*:E2F1:pRB*@nucleus+SWI/SNF@nucleus -> DP1*:E2F1:HDAC1:SWI/SNF:pRB*@nucleus HDAC1@nucleus+DP1*:E2F1:pRB*@nucleus+SWI/SNF@nucleus -> DP1*:E2F1:HDAC1:SWI/SNF:pRB*@nucleus E2F3_alone@cell --> gcyclin A2* gBTRC@genes SUV39H1@nucleus+DP1*:E2F1:HDAC1:SWI/SNF:pRB*@nucleus -> DP1*:E2F1:HDAC1:SUV39H1:SWI/SNF:pRB*@nucleus SUV39H1@nucleus+DP1*:E2F1:HDAC1:SWI/SNF:pRB*@nucleus -> DP1*:E2F1:HDAC1:SUV39H1:SWI/SNF:pRB*@nucleus SUV39H1@nucleus+DP1*:E2F1:HDAC1:SWI/SNF:pRB*@nucleus -> DP1*:E2F1:HDAC1:SUV39H1:SWI/SNF:pRB*@nucleus E2F3_alone@cell -?> gBUB1 gCHEK1@genes CDK7@nucleus MNAT1@nucleus CDK2__pho:cyclin E1*@nucleus CDK2__pho:cyclin E1*__pho@nucleus cyclin H*@nucleus CDK7__pho:MNAT1:cyclin H*@nucleus gCLSPN@genes E2F2_alone@cell --> gMYCN E2F2_alone@cell --> gNPAT gTP73@genes gTERT@genes guPA@genes gUDG1A@genes E2F3_alone@cell --> gPCNA gNRP1@genes E2F3_alone@cell --> gp14ARF* E2F3_alone@cell --> gNPAT E2F3_alone@cell --> gMYCN gmiR-17-92@genes gSKP2@genes gPAC1@genes CDC20@nucleus GSK3B@nucleus E2F1_alone@cell --> gBBC3 CDH1*@nucleus AKT1@nucleus E2F1_alone@cell --> gBCL2 GSK3B__pho@nucleus CDC20__pho@nucleus E2F1_alone@cell -?> gAURKB E2F1_alone@cell --> gAXIN2 MDM2@nucleus E2F1_alone@cell --> gATM E2F1_alone@cell --> gATP5J E2F1_alone@cell --> gAPAF1 DP1*:E2F1:HDAC1:SUV39H1:SWI/SNF:pRB*@nucleus E2F1_alone@cell --> gASK E2F1_alone@cell --> gACTG1 E2F1_alone@cell --> gACTN4 E2F3_alone@cell -?> gMYC E2F3_alone@cell --> gMELK CDK2__pho@nucleus E2F3_alone@cell --> gMYBL2 cyclin E1*__pho@nucleus E2F3_alone@cell --> gMCM7 null@nucleus APC@nucleus DP1*:E2F1@nucleus gSNRPE@genes E2F3_alone@cell -?> gMCM6 gTP53@genes E2F3_alone@cell -?> gKPNA2 E2F8@nucleus E2F7@nucleus E2F3_alone@cell --> gEZH2 gMCM8@genes E2F3_alone@cell --> gEED gFOXO1@genes E2F3_alone@cell --> gGMNN gTK1@genes E2F3_alone@cell -?> gGAB2 E2F5@nucleus E2F6@nucleus E2F4@nucleus CDH1*__pho@nucleus null@nucleus WEE1@nucleus DP1*:E2F1:HDAC1:SWI/SNF:pRB*@nucleus E2F3_alone@cell --> gCDT1 E2F3_alone@cell --> gCNAP1 E2F3_alone@cell --> gDHFR E2F3_alone@cell --> gE2F1 DP1*:E2F1__ace@nucleus APC:CDH1*@nucleus APC:CDC20__pho@nucleus gTHEM2@genes gSTMN1@genes p53*__pho@nucleus - CHEK1__pho__pho@nucleus - CHEK2__pho@nucleus -> p53*__pho__pho@nucleus gTP53BP2@genes PCNA@nucleus gTP53INP1@genes CDC14A@nucleus null@nucleus E2F1_alone@cell --> gCCND3 DP1*:E2F1__ace__pho@nucleus+TOPBP1@nucleus -> DP1*:E2F1__ace__pho:TOPBP1@nucleus DP1*:E2F1__ace__pho@nucleus+TOPBP1@nucleus -> DP1*:E2F1__ace__pho:TOPBP1@nucleus DP1*:E2F1__ace__pho@nucleus+TOPBP1@nucleus -> DP1*:E2F1__ace__pho:TOPBP1@nucleus E2F1_alone@cell --> gcyclin B1* gSUZ12@genes cyclin B1*@nucleus E2F1_alone@cell --> gCDC2 gSSR4@genes E2F1_alone@cell --> gCyclin E* DP1*:E2F1__ace__pho@nucleus E2F1_alone@cell --> gCDC25A E2F1_alone@cell --> gCDC6 E2F1_alone@cell --> gCDKN2C E2F1_alone@cell --> gp21Cip* gTOP2A@genes E2F1_alone@cell --> gcarboxylesterase* gTOPBP1@genes E2F1_alone@cell --> gCDT1 gUBB@genes CDC25C__pho__pho@nucleus gUHRF1@genes PCNA:p21Cip*@nucleus ATM@nucleus - ATM@nucleus -> ATM__pho@nucleus CHEK1@nucleus - ATR@nucleus -> CHEK1__pho__pho@nucleus gSLC3A2@genes p27Kip1*__pho@nucleus gSIVA@genes DP1*:p14ARF*@nucleole cyclin H*@nucleus+CDK7@nucleus+MNAT1@nucleus -> CDK7:MNAT1:cyclin H*@nucleus cyclin H*@nucleus+CDK7@nucleus+MNAT1@nucleus -> CDK7:MNAT1:cyclin H*@nucleus cyclin H*@nucleus+CDK7@nucleus+MNAT1@nucleus -> CDK7:MNAT1:cyclin H*@nucleus gFOXO3a@genes CDK2:cyclin E1*@nucleus - CDK7__pho:MNAT1:cyclin H*@nucleus -> CDK2__pho:cyclin E1*@nucleus gp27Kip*@genes p27Kip1*__pho@cell gECE1@genes E2F1_alone@cell --> gBIRC5 MDM2:p14ARF*@nucleole E2F1_alone@cell --> gBCL2L11 DP1*:p14ARF*@nucleus E2F1_alone@cell --> gCASP8 E2F1_alone@cell --> gCASP7 E2F1_alone@cell --> gCASP3 gSRPR@genes E2F1_alone@cell -?> gBRCA1 gSPAG7@genes gSOAT2@genes E2F1_alone@cell --> gcyclin A2* gSNX19@genes E2F1_alone@cell -?> gCBX5 gSLC25A14@genes E2F1_alone@cell --> gCASP9 GSK3B@nucleus - AKT1@nucleus -> GSK3B__pho@nucleus E2F1_alone@cell --> gEED E2F1_alone@cell --> gE2F7 null@nucleus E2F1_alone@cell -?> gEXOSC8 E2F1_alone@cell --> gEIF2AK2 HP1gamma*@nucleus+DP1*:E2F1:HDAC1:SUV39H1:SWI/SNF:pRB*@nucleus -> DP1*:E2F1:HDAC1:HP1gamma*:SUV39H1:SWI/SNF:pRB*@nucleus HP1gamma*@nucleus+DP1*:E2F1:HDAC1:SUV39H1:SWI/SNF:pRB*@nucleus -> DP1*:E2F1:HDAC1:HP1gamma*:SUV39H1:SWI/SNF:pRB*@nucleus HP1gamma*@nucleus+DP1*:E2F1:HDAC1:SUV39H1:SWI/SNF:pRB*@nucleus -> DP1*:E2F1:HDAC1:HP1gamma*:SUV39H1:SWI/SNF:pRB*@nucleus null@cell E2F1_alone@cell --> gE2F6 E2F1_alone@cell -?> gE2F2 E2F1_alone@cell --> gFGFR2 E2F1_alone@cell --> gEZH2 E2F1_alone@cell --| gFSHR E2F1_alone@cell --> gFHIT CDK2__pho:cyclin E1*:p107*@nucleus DP1*:E2F1:HDAC1:SWI/SNF:pRB*@nucleus - CDK3:cyclin C*@nucleus -> DP1*:E2F1:HDAC1:SWI/SNF:pRB*__pho@nucleus DP1*:E2F1:HDAC1:HP1gamma*:SUV39H1:SWI/SNF:pRB*@nucleus -> DP1*:E2F1:HDAC1:SWI/SNF:pRB*@nucleus+HP1gamma*:SUV39H1@nucleus DP1*:E2F1:HDAC1:HP1gamma*:SUV39H1:SWI/SNF:pRB*@nucleus -> DP1*:E2F1:HDAC1:SWI/SNF:pRB*@nucleus+HP1gamma*:SUV39H1@nucleus DP1*:E2F1:HDAC1:HP1gamma*:SUV39H1:SWI/SNF:pRB*@nucleus -> DP1*:E2F1:HDAC1:SWI/SNF:pRB*@nucleus+HP1gamma*:SUV39H1@nucleus E2F1:p14ARF*@nucleus E2F1:p14ARF*@nucleole gTYMS@genes CHEK1__pho__pho@nucleus E2F1_alone@cell --> gCYC gTRIM55@genes CHEK1@nucleus E2F1_alone@cell --> gCSDA gTUBA3@genes E2F1_alone@cell --> gCox IV* E2F1_alone@cell --> gCNAP1 gZNF451@genes E2F1_alone@cell --> gCHEK2 gZNF83@genes gWWOX@genes gBRD7@genes gUXT@genes gWDR36@genes E2F1_alone@cell -?> gE2F1 E2F1_alone@cell --> gDNMT1 DP1*:E2F1__ace__pho@nucleus E2F1_alone@cell --| gDIRAS3 ATM@nucleus E2F1_alone@cell --> gDHFR DP1*:E2F1__ace__pho:TOPBP1@nucleus E2F1_alone@cell -?> gDDX11 p53*@nucleus - CHEK2__pho@nucleus - ATR@nucleus - ATM__pho:NBS1__pho@nucleus -> p53*__pho@nucleus CHEK2@nucleus - ATM__pho:NBS1__pho@nucleus -> CHEK2__pho@nucleus E2F1_alone@cell --> gNPAT E2F1_alone@cell --> gp14ARF* CDK6:cyclin D1*@cell - p27Kip1*@nucleus - p21Cip*@nucleus -t-> CDK6:cyclin D1*@nucleus E2F1_alone@cell --> gMCM7 E2F1_alone@cell --> gMCM10 E2F1_alone@cell --> gMELK E2F1_alone@cell --> gMYB E2F1_alone@cell --| gMYBL2 E2F1_alone@cell --> gMYC E2F1_alone@cell --> gMYCN E2F1_alone@cell --> gMXD3 CDK4:cyclin D1*__pho@nucleus -t-> CDK4:cyclin D1*__pho@cell CDK4:cyclin D1*@nucleus - GSK3B@nucleus -> CDK4:cyclin D1*__pho@nucleus CDK6:cyclin D1*__pho@nucleus -t-> CDK6:cyclin D1*__pho@cell E2F1_alone@cell --> gPCNA CDK6:cyclin D1*@nucleus - GSK3B@nucleus -> CDK6:cyclin D1*__pho@nucleus p27Kip1*@nucleus+CDK6:cyclin D1*@nucleus -> CDK6:cyclin D1*:p27Kip1*@nucleus p27Kip1*@nucleus+CDK6:cyclin D1*@nucleus -> CDK6:cyclin D1*:p27Kip1*@nucleus p27Kip1*@nucleus+CDK6:cyclin D1*@nucleus -> CDK6:cyclin D1*:p27Kip1*@nucleus p27Kip1*@nucleus+CDK4:cyclin D1*@nucleus -> CDK4:cyclin D1*:p27Kip1*@nucleus p27Kip1*@nucleus+CDK4:cyclin D1*@nucleus -> CDK4:cyclin D1*:p27Kip1*@nucleus p27Kip1*@nucleus+CDK4:cyclin D1*@nucleus -> CDK4:cyclin D1*:p27Kip1*@nucleus E2F1_alone@cell -?> gMCM3 E2F1_alone@cell --> gMCAM E2F1_alone@cell --| gMCL1 E2F1_alone@cell --> gGMNN E2F1_alone@cell --> gH19 E2F1_alone@cell --> gGAB2 E2F1_alone@cell --> gJMY E2F1_alone@cell --> gLGALS1 E2F1_alone@cell --> gHRK E2F1_alone@cell --> gISYNA1 p27Kip1*__pho@nucleus -> WEE1@nucleus - CHEK1__pho__pho@nucleus - CDC2__pho:cyclin B1*@nucleus -> WEE1__pho@nucleus CDC37:CDK4:HSP90_hm2@cell -> CDK4@cell+CDC37:HSP90_hm2@cell CDC37:CDK4:HSP90_hm2@cell -> CDK4@cell+CDC37:HSP90_hm2@cell CDC37:CDK4:HSP90_hm2@cell -> CDK4@cell+CDC37:HSP90_hm2@cell CDK4@cell+cyclin D1*@cell -> CDK4:cyclin D1*@cell CDK4@cell+cyclin D1*@cell -> CDK4:cyclin D1*@cell CDK4@cell+cyclin D1*@cell -> CDK4:cyclin D1*@cell p130*__pho@nucleus -> HSP90_hm2@cell+CDC37:CDK4__don@cell -> CDC37:CDK4:HSP90_hm2@cell HSP90_hm2@cell+CDC37:CDK4__don@cell -> CDC37:CDK4:HSP90_hm2@cell HSP90_hm2@cell+CDC37:CDK4__don@cell -> CDC37:CDK4:HSP90_hm2@cell CDK4__don@cell+CDC37@cell -> CDC37:CDK4__don@cell CDK4__don@cell+CDC37@cell -> CDC37:CDK4__don@cell CDK4__don@cell+CDC37@cell -> CDC37:CDK4__don@cell HSP90@cell -> HSP90_hm2@cell E2F1_alone@cell --> gSERPINE1 E2F7@nucleus --| gCCNE1 E2F7@nucleus --| gCDC6 E2F7@nucleus --| gE2F1 MDM2@nucleus+p53*@nucleus - AKT1@nucleus -> MDM2:p53*@nucleus MDM2@nucleus+p53*@nucleus - AKT1@nucleus -> MDM2:p53*@nucleus MDM2@nucleus+p53*@nucleus - AKT1@nucleus -> MDM2:p53*@nucleus E2F1_alone@cell --> gRBM25 MDM2@nucleus - ATM__pho@nucleus -> MDM2__pho@nucleus E2F1_alone@cell --> gRPA2 NBS1@nucleus - ATM__pho@nucleus -> NBS1__pho@nucleus E2F1_alone@cell --> gRPL8 E2F1_alone@cell --> gRPL32 CDK4__don@cell+p16INK4a*@cell - SERTAD1@cell -> CDK4:p16INK4a*@cell CDK4__don@cell+p16INK4a*@cell - SERTAD1@cell -> CDK4:p16INK4a*@cell CDK4__don@cell+p16INK4a*@cell - SERTAD1@cell -> CDK4:p16INK4a*@cell E2F5@nucleus --| gBIRC5 MDM2@nucleus+p14ARF*@nucleus -> MDM2:p14ARF*@nucleus MDM2@nucleus+p14ARF*@nucleus -> MDM2:p14ARF*@nucleus MDM2@nucleus+p14ARF*@nucleus -> MDM2:p14ARF*@nucleus CDK4__don@cell+p15INK4b*@cell -> CDK4:p15INK4b*@cell CDK4__don@cell+p15INK4b*@cell -> CDK4:p15INK4b*@cell CDK4__don@cell+p15INK4b*@cell -> CDK4:p15INK4b*@cell E2F5@nucleus --> gFSHR CDK6@cell+p16INK4a*@cell -> CDK6:p16INK4a*@cell CDK6@cell+p16INK4a*@cell -> CDK6:p16INK4a*@cell CDK6@cell+p16INK4a*@cell -> CDK6:p16INK4a*@cell E2F5@nucleus --| gESR1 ATM__pho@nucleus+NBS1__pho@nucleus -> ATM__pho:NBS1__pho@nucleus ATM__pho@nucleus+NBS1__pho@nucleus -> ATM__pho:NBS1__pho@nucleus ATM__pho@nucleus+NBS1__pho@nucleus -> ATM__pho:NBS1__pho@nucleus E2F1_alone@cell -?> gRBBP4 E2F1_alone@cell --> gPTGS2 E2F1_alone@cell -?> gRAD51AP1 E2F1_alone@cell --> gPPARG E2F1_alone@cell --> gPPP1R13B E2F1_alone@cell --| gPNRC2 E2F1_alone@cell -?> gp180* CDK6@cell+p15INK4b*@cell -> CDK6:p15INK4b*@cell CDK6@cell+p15INK4b*@cell -> CDK6:p15INK4b*@cell CDK6@cell+p15INK4b*@cell -> CDK6:p15INK4b*@cell E2F1_alone@cell --> gPFKFB* p27Kip1*@nucleus - CDK2__pho:cyclin E1*@nucleus -> p27Kip1*__pho@nucleus E2F1_alone@cell --> gPMAIP1 CDK4:cyclin D1*@cell - p27Kip1*@nucleus - p21Cip*@nucleus -t-> CDK4:cyclin D1*@nucleus E2F2_alone@cell --> gRBL1 E2F1_alone@cell -?> gRBBP8 CDK4:cyclin D1*:p27Kip1*@nucleus - CDK7__pho:MNAT1:cyclin H*@nucleus -> CDK4__pho:cyclin D1*:p27Kip1*@nucleus CDK6:cyclin D1*:p27Kip1*@nucleus - CDK7__pho:MNAT1:cyclin H*@nucleus -> CDK6__pho:cyclin D1*:p27Kip1*@nucleus CDK2:cyclin A2*@nucleus+p27Kip1*@nucleus -> CDK2:cyclin A2*:p27Kip1*@nucleus CDK2:cyclin A2*@nucleus+p27Kip1*@nucleus -> CDK2:cyclin A2*:p27Kip1*@nucleus CDK2:cyclin A2*@nucleus+p27Kip1*@nucleus -> CDK2:cyclin A2*:p27Kip1*@nucleus CDK2:cyclin E1*@nucleus+p27Kip1*@nucleus -> CDK2:cyclin E1*:p27Kip1*@nucleus CDK2:cyclin E1*@nucleus+p27Kip1*@nucleus -> CDK2:cyclin E1*:p27Kip1*@nucleus CDK2:cyclin E1*@nucleus+p27Kip1*@nucleus -> CDK2:cyclin E1*:p27Kip1*@nucleus E2F6@nucleus -?> gCCNB2 E2F6@nucleus -?> gcyclin A2* E2F6@nucleus -?> gCDC2 E2F5@nucleus --| gMYC E2F5@nucleus --| gGMNN E2F6@nucleus --| gCBX5 E2F6@nucleus --| gBRCA1 DP2*:E2F4:HDAC1:SIN3B:SUV39H1:p130*__pho@nucleus HDAC1:SIN3B@nucleus E2F4@nucleus --> gCDT1 E2F4@nucleus -?> gCHEK1 E2F4@nucleus -?> gCHEK2 E2F4@nucleus --| gCLSPN E2F4@nucleus --| gCSTF1 E2F4@nucleus --| gCDC2 E2F4@nucleus --| gCDC6 E2F4@nucleus -?> gCDC20 E2F4@nucleus -?> gCDC25A E2F4@nucleus -?> gCDKN2C E2F4@nucleus --| gESR1 E2F4@nucleus --| gCDT1 E2F4@nucleus -?> gE2F7 E2F4@nucleus --| gEED E2F4@nucleus -?> gCSTF3 E2F4@nucleus -?> gDDX11 E2F4@nucleus -?> gDRF1 E2F4@nucleus -?> gE2F1 E2F4@nucleus -?> gDHFR E2F4@nucleus --| gDIRAS3 E2F3_alone@cell -?> gRRM1 E2F3_alone@cell -?> gRBL1 DP1*:E2F6@nucleus E2F3_alone@cell --> gPPP1R13B p53*@cell E2F3_alone@cell --> gPPARG E2F3_alone@cell -?> gp180* DP1*:E2F6@cell E2F3_alone@cell --> gp68* CDK2:cyclin E1*@nucleus - WEE1@nucleus -> CDK2__pho__pho:cyclin E1*@nucleus CDC2__pho:cyclin B1*@nucleus+p21Cip*__pho@nucleus -> CDC2__pho:cyclin B1*:p21Cip*@nucleus CDC2__pho:cyclin B1*@nucleus+p21Cip*__pho@nucleus -> CDC2__pho:cyclin B1*:p21Cip*@nucleus CDC2__pho:cyclin B1*@nucleus+p21Cip*__pho@nucleus -> CDC2__pho:cyclin B1*:p21Cip*@nucleus WEE1__pho@nucleus CDK2__pho:cyclin E1*@nucleus+p21Cip*@nucleus -> CDK2__pho:cyclin E1*:p21Cip*@nucleus CDK2__pho:cyclin E1*@nucleus+p21Cip*@nucleus -> CDK2__pho:cyclin E1*:p21Cip*@nucleus CDK2__pho:cyclin E1*@nucleus+p21Cip*@nucleus -> CDK2__pho:cyclin E1*:p21Cip*@nucleus CDC25C__pho__pho@cell CDK2:cyclin A2*@nucleus+p21Cip*@nucleus -> CDK2__pho:cyclin A2*:p21Cip*@nucleus CDK2:cyclin A2*@nucleus+p21Cip*@nucleus -> CDK2__pho:cyclin A2*:p21Cip*@nucleus CDK2:cyclin A2*@nucleus+p21Cip*@nucleus -> CDK2__pho:cyclin A2*:p21Cip*@nucleus p21Cip*@nucleus+CDK4:cyclin D1*@nucleus -> CDK4:cyclin D1*:p21Cip*@nucleus p21Cip*@nucleus+CDK4:cyclin D1*@nucleus -> CDK4:cyclin D1*:p21Cip*@nucleus p21Cip*@nucleus+CDK4:cyclin D1*@nucleus -> CDK4:cyclin D1*:p21Cip*@nucleus MGA@nucleus+MAX@nucleus -> MAX:MGA@nucleus MGA@nucleus+MAX@nucleus -> MAX:MGA@nucleus MGA@nucleus+MAX@nucleus -> MAX:MGA@nucleus p21Cip*@nucleus+CDK6:cyclin D1*@nucleus -> CDK6:cyclin D1*:p21Cip*@nucleus p21Cip*@nucleus+CDK6:cyclin D1*@nucleus -> CDK6:cyclin D1*:p21Cip*@nucleus p21Cip*@nucleus+CDK6:cyclin D1*@nucleus -> CDK6:cyclin D1*:p21Cip*@nucleus DP1*:E2F1:SWI/SNF:pRB*__pho__pho@nucleus - CDK2__pho:cyclin E1*@nucleus -?> DP1*:E2F1:pRB*__pho__pho__pho@nucleus+SWI/SNF__pho@nucleus CDC2__pho@nucleus -> CDC2@nucleus E2F4@nucleus -?> gJPH2 E2F4@nucleus -?> gHOXA3 DP1*:E2F1:HDAC1:HP1gamma*:SUV39H1:SWI/SNF:pRB*@nucleus E2F4@nucleus --> gGMNN E2F4@nucleus --| gFGFR1 CDC25C@nucleus - CDC2__pho:cyclin B1*@nucleus -> CDC25C__pho@nucleus E2F4@nucleus --| gFBXO5 gATP5J@genes E2F4@nucleus --| gEZH2 gAPAF1@genes E2F4@nucleus -?> gEXOSC8 gACTN4@genes gACTG1@genes gESR1@genes cyclin C*@nucleus gCSDA@genes CDK3@nucleus gRAD51AP1@genes gMYBL2@genes gHRK@genes E2F4@nucleus --| gATM E2F4@nucleus -?> gMAD2L1 CDK3:cyclin C*@nucleus gFSHR@genes E2F4@nucleus -?> gAURKB E2F4@nucleus -?> gKPNA2 E2F3_alone@cell --> gRRM2 E2F4@nucleus --| gKNTC2 EZH2@nucleus E2F4@nucleus -?> gACR E2F4@nucleus -?> gBTRC E2F4@nucleus -?> gBRCA1 E2F4@nucleus -?> gCBX5 E2F4@nucleus -?> gBUB1 E2F4@nucleus -?> gBARD1 E2F4@nucleus --| gBIRC5 E2F4@nucleus --> gBCL2 p57KIP2*@nucleus MDM2@cell E2F1__pho@nucleus -> pRB*__pho__pho__pho@nucleus - PP1@nucleus -> pRB*@nucleus E2F1@nucleus - TFIIH*@nucleus -> E2F1__pho@nucleus HDAC1@nucleus+SIN3B@nucleus -> HDAC1:SIN3B@nucleus HDAC1@nucleus+SIN3B@nucleus -> HDAC1:SIN3B@nucleus HDAC1@nucleus+SIN3B@nucleus -> HDAC1:SIN3B@nucleus E2F4@nucleus -?> gMETAP2 E2F4@nucleus --| gMCM10 gDIRAS3@genes E2F4@nucleus -?> gMRPL27 CDC2__pho:cyclin B1*@nucleus -> CDC2__pho@nucleus+cyclin B1*@nucleus CDC2__pho:cyclin B1*@nucleus -> CDC2__pho@nucleus+cyclin B1*@nucleus CDC2__pho:cyclin B1*@nucleus -> CDC2__pho@nucleus+cyclin B1*@nucleus E2F4@nucleus -?> gMLH1 E2F4@nucleus -?> gMCM5 E2F4 cofactors@cell E2F4@nucleus -?> gMCM3 gE2F8@genes E2F4@nucleus --> gMCM7 gCHEK2@genes E2F4@nucleus -?> gMCM6 E2F6 cofactors@cell gGAB2@genes gFHIT@genes gp180*@genes gMYC@genes E2F4@nucleus --| gMTHFD1 DP1*:E2F1__ace:PCAF@nucleus E2F4@nucleus --| gcyclin A2* E2F4@nucleus -?> gMSH2 E2F4@nucleus --| gcyclin B1* gFGFR2@genes E2F4@nucleus -?> gCCNB2 DP1*:E2F6:EPC1@nucleus DP1*:E2F6@nucleus+EPC1@nucleus -> DP1*:E2F6:EPC1@nucleus DP1*:E2F6@nucleus+EPC1@nucleus -> DP1*:E2F6:EPC1@nucleus DP1*:E2F6@nucleus+EPC1@nucleus -> DP1*:E2F6:EPC1@nucleus cyclin D1*@cell CDK6@cell DP2*:E2F6@cell -t-> DP2*:E2F6@nucleus E2F4@nucleus --| gMYBL2 E2F6@cell+DP2*@cell -> DP2*:E2F6@cell E2F6@cell+DP2*@cell -> DP2*:E2F6@cell E2F6@cell+DP2*@cell -> DP2*:E2F6@cell DP1*:E2F6@cell -t-> DP1*:E2F6@nucleus E2F4@nucleus -| gNPAT gDNMT1@genes E2F4@nucleus --| gNEK2 gDDX11@genes E2F4@nucleus -?> gMYCN gCNAP1@genes E2F4@nucleus --| gMYC gCDT1@genes E2F4@nucleus --| gPFKFB* E2F4@nucleus --| gPCNA E2F4@nucleus -?> gPBK gEXOSC8@genes E2F4@nucleus -?> gp14ARF* gEIF2AK2@genes CDC2@cell CDK2:cyclin E1*@nucleus CDK2:cyclin A2*@nucleus E2F4@nucleus --| gPLK1 CDK6:cyclin D1*@cell CDK2@nucleus gCDC25A@genes cyclin A2*@nucleus gCASP9@genes cyclin E1*@nucleus gBRCA1@genes cyclin B1*@cell gBIRC5@genes null@nucleus TFIIH*@nucleus E2F1__pho@nucleus CDK6@cell+cyclin D1*@cell -> CDK6:cyclin D1*@cell CDK6@cell+cyclin D1*@cell -> CDK6:cyclin D1*@cell CDK6@cell+cyclin D1*@cell -> CDK6:cyclin D1*@cell DP2*:E2F6@cell DP2*:E2F6@nucleus EPC1@nucleus E2F4@nucleus --| gp68* E2F4@nucleus --| gPOLA E2F4@nucleus -?> gPRKDC gPLK1@genes E2F4@nucleus --| gPPARG gNEK2@genes E2F4@nucleus -?> gRAD51AP1 gPRKDC@genes E2F4@nucleus -?> gPSMA4 gPOLA@genes E2F4@nucleus -?> gRBBP4 gRAD54L@genes E2F4@nucleus -?> gRAD54L gPSMA4@genes E2F4@nucleus -| gRBL1 E2F4@nucleus -?> gRBBP8 gAURKB@genes CDC2@nucleus CDKN3@nucleus CDC2__pho@nucleus CDK4__don@cell gMRPL27@genes gMTHFD1@genes gMSH2@genes E2F4@nucleus --| gRRM1 E2F4@nucleus -| gRQCD1 E2F4@nucleus -?> gRFC5 pRB*__pho__pho__pho@nucleus gCASP8@genes gcyclin B1*@genes DP1*:E2F1:pRB*@nucleus E2F6@cell CDK4:cyclin D1*@cell E2F8@nucleus --| gE2F1 gMETAP2@genes gMLH1@genes E2F8@nucleus --| gCCNE1 gMAD2L1@genes E2F8@nucleus --| gCDC6 gMCM5@genes E2F8@nucleus --| gcyclin A2* gMYCN@genes E2F8@nucleus --| gcyclin B1* gPTGS2@genes E2F4@nucleus --| gRRM2 gCDC6@genes pRB*@nucleus E2F4@nucleus -?> gSIP* gMELK@genes E2F1@nucleus -?> E2F Family@cell E2F7@nucleus -?> gE2F8 E2F Family@cell -?> E2F2_alone@cell E2F Family@cell -?> E2F1_alone@cell E2F1__pho__ace@nucleus SIN3B@nucleus DP1*@nucleus HDAC1@nucleus DP2*:E2F4:p130*@nucleus E2F1@nucleus PCAF@nucleus E2F1_alone@cell --> gTK1 E2F1_alone@cell --> gFOXO1 E2F Family@cell -?> E2F3_alone@cell E2F1_alone@cell --> gTP53 E2F1_alone@cell --> gSNRPE CDK2@nucleus+cyclin E1*@nucleus -> CDK2:cyclin E1*@nucleus CDK2@nucleus+cyclin E1*@nucleus -> CDK2:cyclin E1*@nucleus CDK2@nucleus+cyclin E1*@nucleus -> CDK2:cyclin E1*@nucleus CDK2@nucleus+cyclin A2*@nucleus -> CDK2:cyclin A2*@nucleus CDK2@nucleus+cyclin A2*@nucleus -> CDK2:cyclin A2*@nucleus CDK2@nucleus+cyclin A2*@nucleus -> CDK2:cyclin A2*@nucleus E2F3_alone@cell --> gmiR-17-92 E2F1_alone@cell --> gMCM8 CDK3@nucleus+cyclin C*@nucleus -> CDK3:cyclin C*@nucleus CDK3@nucleus+cyclin C*@nucleus -> CDK3:cyclin C*@nucleus CDK3@nucleus+cyclin C*@nucleus -> CDK3:cyclin C*@nucleus E2F1_alone@cell --> gSKP2 E2F1_alone@cell --> gTERT E2F1_alone@cell --> gPAC1 CDK2:cyclin A2*@nucleus - CDK7__pho:MNAT1:cyclin H*@nucleus -> CDK2__pho:cyclin A2*@nucleus E2F1_alone@cell --> gTP73 gCDCA4@genes p21Cip*__pho@nucleus gCDCA7@genes p21Cip*__pho@cell E2F1_alone@cell --> guPA gPURALPHA@genes E2F1_alone@cell --> gUDG1A p18INK4c*@nucleus E2F1_alone@cell --> gNRP1 E2F3_alone@cell --> gPOLA E2F2_alone@cell --> gECE1 gBMI1@genes E2F8_hm2@nucleus E2F1_alone@cell --> gp27Kip* E2F1_alone@cell --> gRRM2 E2F1_alone@cell --> gFOXO3a p21Cip*__pho@nucleus p19INK4d*@nucleus